CardioTox® Panel
For a comprehensive evaluation of cardiac toxicity with in vivo relevance.
Download CardioTox® Panel PDF
The two most frequently used models in cardiac research are the isolated whole heart and cultured cardiac cells. The cultured cell model is popular because of its versatility, economy and convenience. The neonatal rat cardiomyocyte model enables researchers to study and understand the morphological, biochemical and electrophysiological characteristics of the heart. The model allows not only the study of toxicity of drugs, but also their cardioprotective effects.
The probability that a test compound will produce cardiac toxicity over hepatotoxicity is determined by comparing general toxicity in cardiomyocytes (CM) to toxicity in hepatocytes (Hep).
The mean TC50 in CMs is compared to the mean TC50 in Hep to determine the toxicity index (TI). Activation of
signaling pathways known to initiate adverse cardiac events that may not result in cell death can also be monitored.
If TI = 1 then equal toxicity
If TI < 1 then heart toxicity
If TI > 1 then liver toxicity
The heart toxicity model is a cost-effective way to quickly identify heart-specific toxicity using multiple biochemical endpoints and gene expression markers