A Biochemical Approach to In Vitro Toxicity Testing
Posted Friday, January 14, 2005
CeeTox was featured in an article by Pharmaceutical Discovery entitled “A Biochemical Approach to In Vitro Toxicity Testing.”
The authors describe a new approach to in vitro toxicity testing that is based upon cellular biochemical processes that are essential for survival. The platform combines cell-based assays, multiple endpoint analysis, concentration – response data and a database of nonproprietary drugs and chemicals that ensures a high degree of in vivo predictability.
The information generated enables researchers to rank order compounds based upon wholecell efficacy (IC50) and whole-cell toxicity (TC50) data, understand subcellular targets and perform structure – toxicity relationship analyses – all of which can help identify safer drugs with higher probabilities of success earlier in the development process.