• Dermal Irritation and Corrosion • Ocular Corrosion and Irritation • Percutaneous Absorption • PhotoTox • Endocrine Disruption Screens • Dermal Sensitization • In Vitro Acute OralTox-LD50 • Respiratory Toxicity • AcuteTox™ • CTOX™ Panel • CardioTox® Panel • Renal Toxicity Panel • Drug-Drug Interaction Screen

CeeTox offers the In Vitro Acute Oral Toxicity LD50, the only commercially available non-animal, cell-based model for predicting acute systemic toxicity and the OECD category of toxicity. In a just completed, blinded client study, the assay demonstrated a 91% sensitivity and 78% specificity! Click here for the poster describing this work which was presented at the 7th World Congress on Alternatives and Animal Use in the Life Sciences in Rome.

Acute systemic toxicity testing is the estimation of the human hazard potential of a substance by determining its systemic toxicity in a test system following an acute exposure. Its assessment has traditionally been based on the median lethal dose (LD50) value - an estimate of the dose of a test substance that kills 50% of the test animals. For a substance to have systemic toxic effects, it must be absorbed by the body and distributed by the circulation to sites in the body where it exerts toxic effects.

The CeeToxIn Vitro Acute Oral Toxicity LD50 Panel is designed to provide detailed information on the cytotoxicity of test articles in a multi-parameter, cell-based in vitro model. Results from the panel are used to rank-order test articles based on cytotoxicity, identify potential subcellular targets and mechanisms of toxicity, and provide an estimate (CToxLD50 value) of acute oral toxicity based on the OECD system for categorizing chemicals (Very Toxic, Toxic, Harmful, Unclassified).

In Vitro Acute Oral Toxicity LD50 data results demonstrate a high degree of concordance with known determinations of in vivo LD50 results (see table below).

CeeTox leads the field of in vitro toxicology, with cutting edge models that help you bring safer products to market faster and comply with Amendment 7 and REACH directives. Our robust, multi-parameter approach meets the needs of the personal care, chemical, and pharma/biotech industries.

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Smithers Viscient is hosting a free 90-minute Endocrine Disruptor Screening Program (EDSP) webinar on September 30, 2009 at 10am EST. Jeff Pregenzer, CeeTox Director of Endocrine Studies, will be the first speaker, presenting in vitro testing overview.

Please click here to register.

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CTPA Members only

The CTPA is holding a one-day seminar on the new EC Cosmetics Regulation, re-cast from a directive, on 14 October 2009 at The Royal College of Physicians in London.

While the Regulation has yet to be officially published (delayed to October/November owing to jurist linguists/translation issues), CTPA and other industry experts are working in the Colipa Strategic Project Team Re-cast to develop industry guidance. This guidance will be shared with the European Commission and enforcement authorities to ensure a common understanding.

Mr. Mustafa brings over 20 years of international sales, marketing and business development experience to CeeTox in his current role as Director of Sales and Marketing.

Ahmed earned his MBA from the University of Rochester's Simon School of Business in 1999. Since starting his first company in 1983, he has worked in a variety of industries, including retail photography, optical fiber, medial devices, and science education.

Since joining in vitro toxicology leader CeeTox in 2008, Ahmed has been instrumental in expanding its services beyond pharmaceuticals/biotech to help clients in personal care/cosmetics meet regulatory directives and bring safer products to market.

ACT – American College of Toxicology
Nov. 1-Nov. 3; Wyndham Palm Springs
Palm Springs, CA

Visit us at Booth 115

Join us for the 30th Annual Meeting of the American College of Toxicology (ACT) at the Wyndham Palm Springs. The mission of ACT is to educate, lead and serve professionals in industry, government and academia by promoting the exchange of information and perspectives on safety assessment and the application of new developments related to toxicology.

MichBio will bring its 2009 Expo to the Radisson Plaza Hotel in Kalamazoo, November 3-4. The MichBio Expo is the largest single gathering of biosciences professionals in the state attracting more than 500 biosciences professionals and service providers, and more than 60 exhibitors last year. CeeTox will be exhibiting at this conference and welcomes you to our hometown.

2010

Society of Toxicology 2010
March 7-11; Salt Palace Convention Center
Salt Lake City, Utah

The Society of Toxicology (SOT) Annual Meeting is the largest toxicology meeting and exhibition in the world, attracting more than 6,500 scientists from industry, academia, and government from various countries around the globe. From the keynote address and special lectures, to a wide range of symposia sessions to continuing education courses that cover the basic and the advanced topics of the day, to the workshops, thematic sessions that complement the symposia, roundtables, poster sessions, and award presentations, SOT’s Annual Meeting has something for every attendee.

Look for CeeTox at Booth 200 at the SOT’s ToxExpo 2010 in Salt Lake City, Utah, from March 7-11, 2010. SOT’s Annual Meeting is the forum to showcase toxicology’s novel discoveries.

CeeTox will be exhibiting in Space E114 in Hall 7 at in-cosmetics to be held at Porte de Versailles, Paris, France April 13-15, 2010.

Staged annually in spring in a major European city, in-cosmetics brings together the world’s leading cosmetics suppliers, R&D, production and marketing specialists and showcases the most diverse range of new and innovative cosmetics ingredients and services. Offering a crucial insight into future scientific advances, emerging trends and regulations in an unrivaled educational program, in-cosmetics is the most comprehensive source of industry expertise and the most effective formula for developing business opportunities.

The Cosmetic Science Conference will be your opportunity to learn from an exciting new-line of industry experts.

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NYSCC Suppliers’ Day
May 12-13; New Jersey Convention and Exposition Center
Raritan Center
Edison, NJ

We exhibited at Booth 1231 at the New York Society of Cosmetic Chemists Suppliers’ Day, sharing the booth with SkinEthic. The theme of this year’s show was Innovate for a Greener World. The NYSCC Suppliers’ Day is one of the largest events of its kind in the world.

Sustainable Fragrances for Cleaning Products
June 3-5, 2009
Marriott Washington
Washington, DC

Dr. James McKim presented a special session at the Sustainable Fragrances for Cleaning Products Conference 2009 on Friday, June 5.

Dr. McKim discussed the science behind determining allergic response and sensitization to fragrance. He developed CeeTox’s novel in vitro screen SenCeeTox that tests for the potential to cause skin sensitization without the use of animals, demonstrating a high correlation to LLNA EC3 values, the current validated method.

The conference addressed the most salient issues facing this market, including definitions of “green” and “sustainable” that are meaningful for all constituent industries, and the creation of a list of criteria for “green” fragrances developed by the EPA’s DfE (Design for the Environment) program and RIFM, the Research Institute for Fragrance Materials.

Smithers Viscient hosted a half-day Endocrine Disruptor Screening Program (EDSP) seminar in Research Triangle Park, North Carolina on August 12th 2009.

Scientists specializing in each field of testing discussed their experience with Tier 1 screening assays, and presenters gave comprehensive explanations of the prescribed endpoints for each assay.

In vivo testing overview, Susan Borghoff, PhD, DABT, Director, Investigative Toxicology Division, Integrated Laboratory Systems, Inc. (ILS)

Ecotoxicology testing overview, Arthur Putt, Technical Consultant, Springborn Smithers

In vitro testing overview, Jeff Pregenzer, Director of Endocrine Studies, CeeTox

WC7 World Congress
Sept. 1-3; Cavalieri Hotel
Rome, Italy

Visit us at Booth C14

The World Congresses on Alternatives & Animal Use in the Life Sciences are the longest running series of international scientific conferences dedicated to the replacement, reduction, and refinement (3Rs) of animal use in research and safety testing. These conferences have been held every 2-3 years since 1993 and have attracted a large international group of stakeholders and leading experts in the development and use of methods that replace, reduce, and/or refine (3Rs) animal-based laboratory methods.

Dr. Colleen Toole, Director of Project Management, presented the following four posters:

- An In Vitro Model for Assessing the Effectiveness of Antioxidants in Cosmetics - Poster 157

- Culture, Characterization, and In Vitro Toxicity of Arsenic in Mouse Primary Uroepithelial Cells - Poster 158

- Identifying Respiratory Toxicity Using the Epiarway Human 3-D Model Combined with Multiple Endpoint Analysis - Poster 159

- A New In Vitro Method for Identifying Skin Sensitizers and Predicting LLNA EC3 Values - Poster 160

The Endocrine Disruptor Screening Program: What Can Screening Results Tell Us About Potential Adverse Endocrine Effects?

The ISRTP 2009 Endocrine Workshop examined EPA’s proposed EDSP Tier 1 screening battery. EPA will soon require chemical manufacturers, specifically manufacturers and importers of pesticide active and inert ingredients, to screen specific products for potential endocrine activity using a predetermined set of screening assays developed under the Agency’s Endocrine Disruptor Screening Program (EDSP). 

The goal of the ISRTP 2009 Endocrine workshop is to expand the dialogue among EPA, the regulated community, experts in endocrine testing and other interested parties for the purpose of developing appropriate guidance and procedures for interpreting and using EDSP screening data.

Experts discussed the strengths and weaknesses of each assay and elucidated the potential uses of data generated by those assays. They also examined how currently available data might be used to avoid duplicative screening. The workshop discussions highlighted data gaps, data needs and potential alternative screening and testing methods. Regulatory and legal experts examined legal issues raised by the EDSP program and text orders. Attendees included potential testing order recipients, lawyers, consultants and regulators.

CeeTox shared a display table with Smithers Viscient at the reception on Sept. 9.

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