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• Dermal Irritation and Corrosion |
On May 19, 2010, CeeTox announced that it had recently purchased certain assets formerly owned by ADMETRx Inc. This asset purchase increases CeeTox' existing ADME capabilities and is yet another step in its strategy to expand its range of in vitro service offerings.
Dr. Phil Burton, former co-founder, CEO, and Chief Scientific Officer of ADMETRx, has joined CeeTox as Director of ADME Services. In addition, many other former ADMETRx scientists have joined CeeTox to augment its scientific staff.
CeeTox specializes in the development of new cutting edge in vitro assays and the deployment of validated in vitro models, each designed to identify and accurately predict in vitro toxicity. The company offers individual assays and assay panels specific to the needs of personal care, cosmetic, pharmaceutical, chemical and medical device industries. Its assays comply with the applicable requirements of GLP, OECD, REACH, US EPA and the EU Cosmetics Directive.
CeeTox offers a full service array of capabilities in ADME profiling, data integration, and predictive modeling to advance your preclinical drug development activities.
Led by ADME expert Dr. Philip Burton, this group has been created to assure our pharmaceutical and biotech customers achieve their drug discovery goals. Whether it is to assist in managing capacity issues or to develop sophisticated multi-criteria optimization approaches, the ADME research group is there to work with you.
Their advanced techniques and technologies enable our customers to make informed decisions that save money and dramatically improve the effectiveness of the drug discovery process. This is accomplished by providing high quality biopharmaceutical data to support making candidate advancement decisions. Given the growing concern that perfectly good drug candidates have probably been eliminated too early in drug discovery by reliance on poor quality, high throughput ADMET data to make such candidate advancement decisions, we have developed experimental methods focused on providing quality data to best support these decisions.
Specific ADME profiling includes:
• Solubility
• Permeability
• Transporter characterization
• Metabolic stability
• Metabolic inhibition
• Metabolite ID
• Protein affinity
• Partition coefficient (Log P/Log D)
Beyond Animal Testing - A Novel Alternative Method for Detecting Skin Sensitizing Chemicals
In Europe, two pieces of legislation, REACH and Amendment VII to the Cosmetics Directive, have accelerated the development of alternative toxicology testing methods. CeeTox' Dr. James McKim was interviewed on the benefits of using in vitro methods, rather than in vivo testing on animals, which can predict not only whether a chemical or cosmetic product will be negative or positive as a sensitizer (upon repeated dermal exposure, the chemical induces an immunological response) but also places it in a potency category. This method offers a rapid, cost effective method of identifying chemical sensitizers without the use of animals.
Read the article published in CHEManager 2-3/2010, www.chemanager-online.com/en
Building a Tiered Approach to In Vitro Predictive Toxicity Screening: A Focus on Assays with In Vivo Relevance
James M. McKim, Jr.
The evaluation of adverse effects and the development of toxicity profiles around new chemical entities can greatly improve the selection process of new drug candidates. This in turn should reduce compound risk and increase the probability of success during preclinical animal studies and clinical trials. Ideally, early screening programs should begin during the hit-to-lead phase and continue through candidate selection. A decision tree that incorporates physical chemical, ADME, potency, protein binding, and toxicity should be developed and adhered to during the discovery process. Multiple endpoint analysis, concentration response curves, temporal relationships, metabolic stability and metabolic activation are essential to building a robust screening program. The platform used to collect the data is not as important as the quality of the data and the process used to interpret the data. In vitro toxicity data should be linked to an in vivo parameter that can be easily measured and is closely associated with toxicity. In vitro toxicity data should not be viewed in isolation, but rather combined with other key parameters and characteristics of a successful drug in order to make the most informed selection of new drug candidates.
Publication: Combinatorial Chemistry & High Throughput Screening
2010
IUTOX 2010 - XII International Congress of Toxicology
July 19-23, 2010
Palau de Congressos de Barcelona (Fira de Barcelona)
Barcelona, Spain
The Congress will encourage interaction between Academia, Industry, Regulators and Experts in Human (clinical and epidemiology) and Environmental Toxicology. Chemical Safety increasingly requires integrated approaches to achieve successful possibilities of the innovative applications and transfer of the results of R&D giving added values with safety to human health and the environment. While we will not be attending, CeeTox is a contributor to this Congress.
"The Power of Outsourcing in Early through Preclinical Drug Development"
Sept 9, 2010
4:30pm to 9:00pm
Hyatt Regency
La Jolla, CA
A group of companies will present a package with capabilities of a 'one-stop-shop,' with multi-service offerings across the R&D spectrum. It can also be considered as a package that is offered through multi-disciplinary partners as per the project requirement.
Companies presenting include CeeTox, MPI, Velesco, Kalexsyn, Jasper Clinic, Metabolan, and Grace Furman, Ph.D., CEO/President of Paracelsus, Inc.
Hosted by San Diego non-profit life science networking group (IALSN, www.ialsn.org, a Biocom Member).
26th International IFSCC (International Federation Societies of Cosmetic Chemists) Congress - Innovation & Responsibility: Cosmetics Forever
Sept. 20-23, 2010
Sheraton Buenos Aires Hotel & Convention Center
Buenos Aires, Argentina
The 26th Congress in 2010 will be a showcase for the presentation of research studies. These studies are representative of the high level attained by cosmetic science, which, on the foundations of innovation and responsibility, provides us with more effective, higher technology products, safer for both the consumer and the environment.
Dr. James McKim will be giving both an oral presentation and a poster at this Congress. The oral presentation, A New In Vitro Method for Identifying Skin Sensitizers and Predicting LLNA EC3 Values will be given Wed., Sept 22 at 10am. The poster to be presented is Predicting Acute Oral Toxicity (LD50) with an In Vitro Cell-Based System. The poster will be displayed from Sept 21-23.
ACT - American College of Toxicology
Nov. 7-10, 2010
Marriott Waterfront Hotel
Baltimore MD
Join us for the 31st Annual Meeting of the American College of Toxicology (ACT) at the Baltimore Marriott Waterfront Hotel, on Nov. 7-10, 2010. The mission of ACT is to educate, lead and serve professionals in industry, government and academia by promoting the exchange of information and perspectives on safety assessment and the application of new developments related to toxicology.
CeeTox will be exhibiting at booth 159.
AAPS - American Association of Pharmaceutical Scientists
Nov. 15-17, 2010
Morial Convention Center
New Orleans, LA
Every three to four years, the International Pharmaceutical Federation (FIP) organizes a Pharmaceutical Sciences World Congress (PSWC). Each year, the American Association of Pharmaceutical Scientists (AAPS) organizes the AAPS Annual Meeting and Exposition.
In 2010, FIP and AAPS will hold the PSWC and the Annual Meeting together in New Orleans, LA at the Morial Convention Center from November 14-18 (the expo runs from Nov. 14-17). The scientific theme is: Improving Global Health Through Advances in Pharmaceutical Sciences.
The joint meeting will include:
• A forum for the exchange of ideas and information about the sciences that the organizations represent
• Continuing professional development for individual members and related professionals
• An introduction of the latest technological advances
Visit CeeTox at Booth 3204
2011
Society of Toxicology 2011
March 7-9, 2011
Washington Convention Center
Washington, DC
CeeTox will be exhibiting in Booth 307
The Society of Toxicology (SOT) Annual Meeting is the largest toxicology meeting and exhibition in the world, attracting more than 6,500 scientists from industry, academia, and government from various countries around the globe. From the keynote address and special lectures, to a wide range of symposia sessions to continuing education courses that cover the basic and the advanced topics of the day, to the workshops, thematic sessions that complement the symposia, roundtables, poster sessions, and award presentations, SOT's Annual Meeting has something for every attendee.
in-cosmetics 2011
March 29-31, 2011
Fiera, Milano
Milan, Italy
CeeTox will be exhibiting in Space B93
Staged annually in spring in a major European city, in-cosmetics brings together the world's leading cosmetics suppliers, R&D, production and marketing specialists and showcases the most diverse range of new and innovative cosmetics ingredients and services. Offering a crucial insight into future scientific advances, emerging trends and regulations in an unrivaled educational program, in-cosmetics is the most comprehensive source of industry expertise and the most effective formula for developing business opportunities.
Sustainable Fragrances 2010
May 20-21, 2010
Washington, DC
Dr. Colleen Toole presented In Vitro Tox 101, providing history and background on alternative testing on Friday, May 21. CeeTox has recently introduced the novel in vitro skin sensitization screen, "SenCeeTox," that tests for the potential of an individual ingredient or complex mixture to elicit a skin sensitization reaction without the use of animals. The assay demonstrates a high correlation of LLNA EC3 values, the current validated method.
The conference addressed the most salient issues facing this market, including definitions of "green" and "sustainable" that are meaningful for all constituent industries, and the creation of a list of criteria for "green" fragrances developed by the EPA's DfE (Design for the Environment) program and the RIFM, the Research Institute for Fragrance Materials. CeeTox also had a booth exhibit at this conference.
We look forward to publishing these newsletters on a quarterly basis. Your feedback is welcome. What would you like to hear about in upcoming issues? Contact us at info@ceetox.com or 269.353.5555.
